Informe de análisis del tamaño, la participación y las tendencias del mercado global de cromatografía de fluidos supercríticos: panorama general del sector y pronóstico hasta 2033

Tamaño del mercado de la cromatografía de fluidos supercríticos

• El tamaño del mercado global de cromatografía de fluidos supercríticos se valoró en USD 1.63 mil millones en 2025  y se espera que alcance  los USD 2.25 mil millones para 2033 , con una CAGR del 4,12% durante el período de pronóstico.
• El crecimiento del mercado está impulsado principalmente por la creciente adopción de técnicas analíticas avanzadas en la investigación farmacéutica, biotecnológica y académica, respaldadas por la creciente demanda de tecnologías de separación más rápidas, más eficientes y ambientalmente sostenibles.
• Además, el creciente énfasis en el análisis de alto rendimiento, la mejora de las separaciones quirales y la reducción del consumo de disolventes están posicionando la cromatografía de fluidos supercríticos como una alternativa preferida a la cromatografía líquida convencional. Estos factores combinados están acelerando la adopción de los sistemas SFC, lo que mejora significativamente la trayectoria de crecimiento general del mercado.

Análisis del mercado de la cromatografía de fluidos supercríticos

• La cromatografía de fluidos supercríticos, que permite una separación rápida y de alta eficiencia de compuestos complejos, se adopta cada vez más en los laboratorios químicos, alimentarios y biomédicos debido a su alta resolución, uso reducido de solventes y compatibilidad con aplicaciones analíticas y preparativas.
• La creciente demanda de sistemas de cromatografía de fluidos supercríticos está impulsada principalmente por la creciente adopción de técnicas analíticas avanzadas, el creciente enfoque en soluciones de cromatografía sostenibles y ecológicas y la expansión del uso en análisis químicos y biomédicos.
• América del Norte dominó el mercado de cromatografía de fluidos supercríticos con la mayor participación en los ingresos del 39,6 % en 2025, impulsada por una infraestructura de investigación avanzada, la adopción temprana de tecnologías de cromatografía y la fuerte presencia de los principales fabricantes de instrumentación analítica, con EE. UU. contribuyendo con la mayor parte de la demanda regional.
• Se espera que Asia-Pacífico sea la región de más rápido crecimiento en el mercado de cromatografía de fluidos supercríticos durante el período de pronóstico, respaldada por la expansión de los laboratorios analíticos, el crecimiento de la fabricación de productos farmacéuticos y químicos y el aumento de las inversiones en I+D en las economías emergentes.
• El segmento analítico dominó el mercado de cromatografía de fluidos supercríticos con una participación de mercado del 46,8 % en 2025, atribuido a su amplia aplicación en el análisis químico de rutina, el desarrollo de métodos y el control de calidad en diversas industrias de uso final.

Alcance del informe y segmentación del mercado de cromatografía de fluidos supercríticos

Tendencias del mercado de la cromatografía de fluidos supercríticos

Cambio hacia tecnologías de separación ecológicas y de alta velocidad

• Una tendencia significativa y en aceleración en el mercado global de cromatografía de fluidos supercríticos es la creciente preferencia por técnicas de separación ambientalmente sostenibles y de alta velocidad, impulsada por la creciente presión regulatoria para reducir el uso de solventes orgánicos y mejorar la eficiencia del laboratorio.
  • Por ejemplo, los sistemas SFC modernos introducidos por los principales fabricantes de instrumentos analíticos enfatizan fases móviles basadas en CO₂ reducidas combinadas con tecnologías de columna avanzadas para ofrecer tiempos de ejecución más rápidos en comparación con la cromatografía líquida convencional.
• De manera aconsejable, las innovaciones en curso en la instrumentación SFC están permitiendo una resolución mejorada, una reproducibilidad mejorada y un mejor rendimiento en separaciones de compuestos complejos, particularmente para analitos quirales y no polares, lo que hace que la tecnología sea cada vez más atractiva para flujos de trabajo analíticos rutinarios y avanzados.
• La integración del manejo automatizado de muestras, detectores avanzados y configuraciones de sistemas híbridos está mejorando aún más el rendimiento analítico y la facilidad de uso, lo que permite a los laboratorios incorporar sin problemas SFC en las plataformas de cromatografía existentes.
• Esta tendencia hacia soluciones de cromatografía más rápidas, más ecológicas y más versátiles está transformando las prácticas de laboratorio, con empresas como Waters y Agilent desarrollando sistemas SFC de última generación centrados en la escalabilidad, el cumplimiento y la eficiencia operativa.
• La demanda de tecnologías de separación sostenibles y de alto rendimiento está aumentando constantemente en los sectores de investigación farmacéutica, química, alimentaria y académica, lo que refuerza la cromatografía de fluidos supercríticos como una alternativa estratégica a los métodos tradicionales.
• La creciente adopción de plataformas híbridas SFC-LC permite a los laboratorios aprovechar múltiples técnicas de separación dentro de un único flujo de trabajo, mejorando la flexibilidad operativa y la utilización.

Dinámica del mercado de la cromatografía de fluidos supercríticos

Conductor

Creciente demanda de técnicas analíticas eficientes y sostenibles

• La creciente necesidad de métodos analíticos rápidos, de alta resolución y respetuosos con el medio ambiente en las industrias farmacéutica, química y alimentaria es un factor clave que impulsa la adopción de la cromatografía de fluidos supercríticos.
  • Por ejemplo, las compañías farmacéuticas están ampliando el uso de SFC en los flujos de trabajo de desarrollo de fármacos para acelerar las separaciones quirales y el perfil de impurezas, al tiempo que reducen significativamente el consumo de solventes.
• A medida que las agencias reguladoras continúan enfatizando la solidez, precisión y sostenibilidad del método, los laboratorios adoptan cada vez más SFC para cumplir con estrictos requisitos de calidad y cumplimiento.
• Además, el creciente volumen de pruebas analíticas en el descubrimiento de fármacos, el control de calidad y la investigación química está impulsando la demanda de técnicas que ofrezcan un análisis más rápido sin comprometer la precisión.
• The ability of supercritical fluid chromatography to support both analytical and preparative applications enhances its value proposition, encouraging wider adoption across multiple end-use industries
• The combination of performance efficiency, cost savings from reduced solvent usage, and alignment with green chemistry initiatives is strongly propelling market growth
• Expanding pharmaceutical pipelines and increasing complexity of chemical entities are further driving demand for advanced separation technologies such as SFC
• Rising investments in analytical laboratory infrastructure, particularly in emerging economies, are supporting increased deployment of supercritical fluid chromatography systems

Restraint/Challenge

High System Costs and Technical Complexity

• The relatively high initial investment required for supercritical fluid chromatography systems, along with associated maintenance and training costs, presents a notable challenge to widespread market adoption
  • For instance, small and mid-sized laboratories may hesitate to adopt SFC due to the capital expenditure involved and the need for specialized expertise to operate and optimize the systems effectively
• The technical complexity of method development in SFC, including pressure optimization and modifier selection, can act as a barrier for laboratories accustomed to conventional liquid chromatography techniques
• In addition, limited awareness and familiarity with SFC among some end users can slow adoption, particularly in emerging markets with constrained analytical infrastructure
• While technological advancements are improving system usability, concerns related to operational complexity and return on investment remain for cost-sensitive users
• Overcoming these challenges through user-friendly system designs, training initiatives, and cost-effective product offerings will be essential for sustaining long-term growth in the supercritical fluid chromatography market
• Limited availability of standardized SFC methods across industries can create validation challenges and slow regulatory acceptance
• Dependence on specialized consumables and columns may increase long-term operating costs, restraining adoption among budget-constrained laboratories

Supercritical Fluid Chromatography Market Scope

The market is segmented on the basis of type, system, product, application, and end user.

• By Type

On the basis of type, the supercritical fluid chromatography market is segmented into pre-packed columns and empty columns. The pre-packed columns segment dominated the market in 2025, driven by its ease of use, consistent performance, and reduced method development time. Laboratories prefer pre-packed columns as they ensure reproducibility and reliability, which are critical for regulated environments such as pharmaceutical and food testing labs. Pre-packed columns minimize variability between analyses and reduce the need for in-house packing expertise. In addition, manufacturers provide a wide range of stationary phases tailored for specific applications, further strengthening adoption. Their compatibility with modern SFC systems supports seamless workflow integration and reduces setup errors.

The empty columns segment is expected to witness the fastest growth during the forecast period, fueled by increasing demand for customized separations. Advanced research laboratories and specialized analytical facilities favor empty columns for flexibility in packing specific stationary phases. This enables optimization for niche applications such as complex chiral separations and preparative-scale purification. Growing research activity and innovation-driven laboratories are key contributors to this growth. Furthermore, empty columns allow experimentation with new stationary phases, which supports method development in cutting-edge research.

• By System

On the basis of system, the market is segmented into analytical, hybrid, semi-preparative, and preparative systems. The analytical system segment dominated the market in 2025 with a market share of 46.8%, owing to its widespread use in routine chemical analysis, quality control, and method development. Analytical SFC systems offer high throughput, excellent resolution, and reduced solvent consumption, making them suitable for daily laboratory operations. Their compact design and compatibility with detectors such as mass spectrometry further enhance adoption. Regulatory compliance requirements also favor analytical systems due to their precision and reproducibility. Analytical systems are widely used across pharmaceutical, chemical, and food laboratories for standard testing and method validation.

The hybrid system segment is anticipated to witness the fastest growth during the forecast period, driven by its ability to combine liquid chromatography and supercritical fluid chromatography within a single platform. Hybrid systems provide operational flexibility and allow laboratories to handle a broader range of compounds. This versatility reduces capital investment by eliminating the need for multiple standalone systems. Increasing demand for multifunctional analytical platforms is accelerating adoption. Hybrid systems are particularly attractive to research institutions requiring high adaptability and integration with existing workflows.

• By Product

On the basis of product, the market is segmented into instruments, kits, reagents, and consumables. The instruments segment held the largest market share in 2025, supported by continuous technological advancements and replacement demand for advanced SFC systems. Instruments represent high-value purchases and are essential for establishing SFC capabilities within laboratories. Increasing adoption of automated and high-performance systems further strengthens this segment. Instrument upgrades to support hybrid and preparative applications also contribute to dominance. Instruments also provide scalability for increasing laboratory workloads and complex analytical tasks. Manufacturers often bundle service contracts with instruments, increasing their attractiveness to end users.

The kits, reagents, and consumables segment is projected to grow at the fastest rate during the forecast period, driven by recurring demand from routine analytical operations. As installed bases of SFC instruments expand globally, consumption of columns, reagents, and consumables increases steadily. This segment benefits from repeat purchases and long-term laboratory usage. Growing emphasis on method optimization and application-specific consumables further supports growth. Consumables also include specialty modifiers and solvents required for chiral separations. This steady demand ensures recurring revenue for manufacturers and distributors.

• By Application

On the basis of application, the market is segmented into chemical analysis, food product analysis, biomedical analysis, and others. The chemical analysis segment dominated the market in 2025, attributed to extensive use of SFC in separation, identification, and purity analysis of complex chemical compounds. Chemical laboratories favor SFC for its speed, efficiency, and reduced solvent requirements. Its effectiveness in handling nonpolar and chiral compounds makes it a preferred analytical technique. Increasing chemical research and industrial testing activities support sustained dominance. The segment also benefits from regulatory mandates requiring precise chemical characterization. In addition, SFC enables rapid high-throughput testing, enhancing laboratory productivity.

The biomedical analysis segment is expected to be the fastest growing during the forecast period, driven by rising pharmaceutical and biotechnology research. SFC is increasingly utilized for drug discovery, impurity profiling, and chiral drug analysis. The growing complexity of biomedical compounds and need for precise analytical methods are fueling adoption. Expanding healthcare R&D investments further contribute to rapid growth. Biomedical research often demands minimal solvent usage and rapid separation, both addressed by SFC. Academic and hospital laboratories are adopting SFC to accelerate therapeutic development workflows.

• By End User

On the basis of end user, the market is segmented into food and beverage industry, hospitals/clinics, nutraceutical companies, environmental agencies, pharmaceutical and biotechnology industry, cosmetic industry, government laboratories, and research institutes. The pharmaceutical and biotechnology industry segment dominated the market in 2025, supported by extensive use of SFC in drug development, quality control, and regulatory testing. The industry benefits from SFC’s ability to deliver high-resolution separations with lower solvent consumption. Increasing pharmaceutical pipelines and stringent quality standards reinforce dominance. SFC is widely used in both analytical and preparative workflows within this sector. Large-scale pharmaceutical companies prioritize SFC to improve throughput and reduce environmental impact. The demand for high-precision analytical techniques also drives sustained adoption in biotech research.

The research institutes segment is anticipated to witness the fastest growth during the forecast period, driven by rising academic and government-funded research activities. Research institutes increasingly adopt SFC for advanced analytical studies and method innovation. Growing collaboration between academia and industry further supports system installations. Continuous focus on analytical advancements positions research institutes as a key growth contributor. The flexibility of SFC systems allows experimentation with new stationary phases and hybrid methods. In addition, research funding initiatives in emerging economies accelerate adoption of modern analytical platforms.

Supercritical Fluid Chromatography Market Regional Analysis

• North America dominated the supercritical fluid chromatography market with the largest revenue share of 39.6% in 2025, driven by advanced research infrastructure, early adoption of chromatography technologies, and the strong presence of leading analytical instrumentation manufacturers, with the U.S. contributing the majority of regional demand
• Laboratories in the region extensively utilize SFC for pharmaceutical quality control, method development, and chemical analysis due to its high efficiency, reproducibility, and reduced solvent consumption compared to conventional chromatography techniques
• The widespread adoption is further supported by significant R&D investments, a large base of academic and industrial research institutions, and regulatory emphasis on robust, validated analytical methods, making SFC a preferred choice for analytical and preparative workflows

U.S. Supercritical Fluid Chromatography Market Insight

The U.S. supercritical fluid chromatography market captured the largest revenue share of 82% in North America in 2025, driven by strong pharmaceutical, biotechnology, and chemical research activities. Laboratories increasingly rely on SFC for high-throughput analysis, chiral separations, and impurity profiling. The growing emphasis on environmentally sustainable analytical methods, coupled with regulatory requirements for precise and reproducible testing, further propels adoption. Advanced automated and hybrid SFC systems are being integrated into both industrial and academic labs. In addition, the presence of leading instrument manufacturers and a technologically inclined research ecosystem supports continuous market growth. The increasing use of SFC in method development, quality control, and preparative applications positions the U.S. as the regional market leader.

Europe Supercritical Fluid Chromatography Market Insight

The Europe supercritical fluid chromatography market is projected to expand at a substantial CAGR during the forecast period, driven by stringent regulatory frameworks, the growing pharmaceutical manufacturing base, and increasing adoption of green analytical technologies. Laboratories in Germany, France, and Switzerland prioritize high-resolution, reproducible separation methods for complex chemical and chiral compounds. The rise in research and development initiatives, coupled with the growing demand for environmentally sustainable processes, is fostering market growth. SFC adoption is increasing across both industrial and academic laboratories for chemical analysis, drug development, and quality control. Europe’s emphasis on innovation and compliance strengthens the preference for SFC over conventional techniques. Rising collaborations between research institutions and pharmaceutical companies further accelerate the market.

U.K. Supercritical Fluid Chromatography Market Insight

The U.K. supercritical fluid chromatography market is anticipated to grow at a noteworthy CAGR during the forecast period, supported by expanding pharmaceutical R&D, advanced analytical laboratories, and growing awareness of sustainable analytical methods. Adoption is particularly strong in chemical, pharmaceutical, and academic research applications. Increasing demand for chiral separations and high-throughput analytical methods is encouraging laboratories to integrate SFC systems. The presence of a robust regulatory environment ensures preference for validated, precise, and reproducible separation technologies. Furthermore, the integration of SFC with mass spectrometry and hybrid platforms is gaining traction. The U.K.’s focus on innovation, research collaborations, and green analytical techniques underpins sustained market growth.

Germany Supercritical Fluid Chromatography Market Insight

The Germany supercritical fluid chromatography market is expected to expand at a considerable CAGR during the forecast period, fueled by the country’s advanced pharmaceutical, chemical, and research infrastructure. High demand for precise, reproducible, and sustainable analytical methods is driving adoption. Laboratories prioritize SFC for chiral separations, impurity profiling, and quality control in compliance with strict regulatory standards. Germany’s emphasis on technological innovation and environmental sustainability supports the integration of green analytical methods such as SFC. Academic and industrial research institutions are increasingly adopting SFC for both analytical and preparative applications. In addition, the preference for hybrid and automated systems is contributing to steady market growth.

Asia-Pacific Supercritical Fluid Chromatography Market Insight

The Asia-Pacific supercritical fluid chromatography market is poised to grow at the fastest CAGR of 25% during 2026–2033, driven by rapid expansion of pharmaceutical, biotechnology, and chemical industries. Increasing R&D investments, technological advancements, and government initiatives promoting green and advanced analytical laboratories are key growth drivers. Countries such as China, Japan, and India are seeing rising adoption of SFC in quality control, method development, and drug discovery workflows. The expanding manufacturing base for analytical instruments and components enhances affordability and accessibility. Furthermore, the growing focus on high-throughput and sustainable analysis solutions is encouraging widespread adoption across research and industrial labs.

Japan Supercritical Fluid Chromatography Market Insight

The Japan supercritical fluid chromatography market is gaining momentum due to the country’s advanced pharmaceutical and chemical research ecosystem, strong focus on analytical innovation, and adoption of green technologies. SFC systems are increasingly used in quality control, chiral separations, and drug development applications. The integration of SFC with mass spectrometry and hybrid platforms enhances analytical capabilities. Laboratories are also adopting automated systems to improve efficiency and reproducibility. Japan’s aging population and increasing healthcare R&D are driving demand for reliable and efficient analytical workflows. The emphasis on sustainability and regulatory compliance further supports market expansion in the region.

India Supercritical Fluid Chromatography Market Insight

El mercado indio de cromatografía de fluidos supercríticos representó la mayor cuota de mercado en ingresos en Asia-Pacífico en 2025, impulsado por la rápida industrialización, la expansión de la investigación farmacéutica y química, y la creciente adopción de instrumentos analíticos avanzados. India se está consolidando como un centro de investigación analítica y desarrollo de métodos, con el apoyo de laboratorios académicos e industriales. El creciente enfoque en la química analítica ecológica y las separaciones de alto rendimiento está impulsando la demanda de sistemas de cromatografía de fluidos supercríticos (SFC). La fabricación nacional y la disponibilidad de instrumentos de SFC asequibles impulsan aún más el crecimiento del mercado. El aumento de la inversión en I+D, las iniciativas gubernamentales para la modernización de laboratorios y la creciente demanda de las industrias farmacéutica, biotecnológica y química siguen impulsando el mercado. La adopción de SFC también está en aumento en la investigación académica para el análisis de compuestos quirales y complejos.

Cuota de mercado de la cromatografía de fluidos supercríticos

La industria de la cromatografía de fluidos supercríticos está liderada principalmente por empresas bien establecidas, entre las que se incluyen:

• Waters Corporation (EE. UU.)
• Agilent Technologies, Inc. (EE. UU.)
• Thermo Fisher Scientific Inc. (EE. UU.)
• Corporación Shimadzu (Japón)
• Corporación JASCO (Japón)
• Novasep Holding SAS (Francia)
• Thar Process Inc. (EE. UU.)
• Supercritical Fluid Technologies, Inc. (EE. UU.)
• Selerity Technologies, Inc. (EE. UU.)
• Knauer Wissenschaftliche Geräte GmbH (Alemania)
• Phenomenex Inc. (EE. UU.)
• Restek Corporation (EE. UU.)
• YMC Co., Ltd. (Japón)
• LEWA GmbH (Alemania)
• Sepiatec GmbH (Alemania)
• Fluitron Inc. (EE. UU.)
• Bruker Corporation (EE. UU.)
• Aurora SFC Systems (EE. UU.)
• Trajan Scientific and Medical (Australia)
• Separaciones Aplicadas (EE. UU.)

¿Cuáles son los desarrollos recientes en el mercado global de cromatografía de fluidos supercríticos?

• En octubre de 2025, se programó la conferencia SFC Europe 2025, la 19.ª Conferencia internacional sobre cromatografía de fluidos supercríticos en columna empaquetada, en Basilea (Suiza), que destacó los avances en las aplicaciones ambientales, alimentarias y farmacéuticas de la SFC y facilitó el intercambio mundial de investigadores sobre mejoras técnicas.
• En mayo de 2025, Shimadzu Asia Pacific anunció una asociación estratégica con Core Separations para brindar soluciones integrales de cromatografía de fluidos supercríticos (SFC) y extracción de fluidos supercríticos (SFE) en el sudeste asiático y el sur de Asia (excluida India), lo que permite flujos de trabajo unificados desde la investigación a escala de laboratorio hasta la producción a gran escala para las industrias de alimentos, nutracéuticos y productos naturales.
• En abril de 2025, LCGC International anticipó la adopción de SFC centrada en la sostenibilidad en el análisis ambiental y alimentario, y destacó el papel cada vez mayor de SFC en la detección de contaminantes a nivel de trazas y la identificación de ultra trazas más allá de las aplicaciones tradicionales de las ciencias de la vida.
• En enero de 2025, una empresa de instrumentación analítica anunció una asociación estratégica con una organización de investigación por contrato para desarrollar flujos de trabajo de SFC integrados, con el objetivo de expandir las aplicaciones de cromatografía ecológica que abarcan la lipidómica y el análisis ambiental, acelerando así la adopción de SFC en campos analíticos emergentes.
• En marzo de 2024, Agilent y Aurora SFC Fusion A5 anunciaron el sistema analítico SFC combinado Agilent Serie 1200, que ofrece una mejora significativa de la sensibilidad y separaciones ultrarrápidas para el análisis de trazas quirales y de impurezas, lo que hace que el SFC sea más accesible para los laboratorios de investigación farmacéutica.
• En febrero de 2024, las comunidades analíticas informaron una renovada atención a las capacidades sostenibles y rentables de SFC, con empresas como Shimadzu mostrando sistemas SFC/SFE totalmente automatizados que reducen drásticamente el uso de solventes al tiempo que mejoran las separaciones quirales y aquirales en flujos de trabajo de rutina.

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