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شركة بيوفارما كوربوريشن تعمل على تطوير أدوية الأورام المرشحة عالية الفعالية LADR (إطلاق الدواء المنشط بالرابط)

يركز قطاع الرعاية الصحية اليوم بشكل أكبر على الأدوية المتخصصة لتوفير علاج أفضل للمرضى. الأدوية عالية الفعالية هي تلك التي تحتوي عادةً على مكونات صيدلانية فعالة عالية الفعالية (HPAPI)، والتي تستخدم جزيئات صغيرة لتحليل أمراض مثل السرطان واضطرابات الجهاز التنفسي والاختلالات الهرمونية. عادةً ما تكون لهذه الأدوية آثار جانبية طفيفة، نظرًا لصياغتها خصيصًا لاستهداف مرض واحد، وهو عامل رئيسي في فعاليتها الكبيرة في تسريع تعافي المريض. هذه الأدوية مناسبة جدًا لعلاج الأمراض المهددة للحياة. يستخدم كل من المصنعين والمطورين اليوم تقنيات وحلولًا جديدة لتطوير أدوية جديدة فعالة للغاية. أعلنت شركة CytRx Corporation مؤخرًا عن إطلاق شركتها الفرعية الجديدة Centurion BioPharma Corporation، والتي ستركز بشكل رئيسي على تطوير أدوية الأورام المرشحة عالية الفعالية LADR (إطلاق الدواء المنشط بالرابط). يقع مكتبها الإداري في لوس أنجلوس، كاليفورنيا. LADR-7 وLADR-8 وLADR-9 وLADR-10 هي مرشحات LADR التي نضجت من قبل فريق الاكتشاف في المختبرات الألمانية ولديها القدرة على التقدم في دراسات تمكين الأدوية الجديدة التجريبية. تم تطوير هذه المرشحات الجديدة باستخدام تقنية LADR الخاصة بالشركة. يمكنها أيضًا التحكم في موقع الورم عن طريق ربط مركب الدواء جزيئيًا بمجرى الدم في الجسم. يمكنها أيضًا تقليل سمية النظام. هذه المنصة الجديدة هي مزيج من كيمياء الرابط الخاصة بالشركة مع تقنية الألبومين بحيث يمكنها نقل العوامل عالية الفعالية إلى الأورام. وفقًا لإريك إل كورتيس، الرئيس التنفيذي ورئيس شركة Centurion BioPharma Corporation، فإن إنشاء هذه الشركة الفرعية الجديدة سيكون مفيدًا للغاية لأنه سيعزز ممتلكات CytRx الصيدلانية ومع التقدم في خط أنابيب مرشحي أدوية LADR عالية الفعالية المرتبطة بالألبومين، سينجحون في جذب عدد كبير من المرخصين. تقنية LADR من شركة سنتوريون بيوفارما هي مجموعة من جزيئات الرابط الجديدة القادرة على نقل الألبومين، ولديها القدرة على الارتباط بحمولات مختلفة مضادة للسرطان. تتميز هذه المركبات بنشاط مضاد للأورام في أنواع مختلفة من سرطانات الأورام، مثل سرطان الرقبة، والمبيض، والورم الميلانيني، وسرطان الخلايا الكلوية، والرئة، والثدي. تسعى الشركة إلى ابتكار جزيئات جديدة من خلال الجمع بين حمولات سامة خلوية فائقة الفعالية وروابط قابلة للضبط.

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