Growing Demand of Biological Fluids Tests Due to Increasing Health Related Issues is Leading to Growth of Global Solid Phase Extraction Market in the forecast period of 2019 to 2026


High Investment Towards Automation of SPE

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The demand of SPE in different field for purification and quantification of the compound or molecules in various industries is increasing. The SPE is generally performed manually sample preparation which requires high man-power and consumes a lot of time. Therefore, to meet the need for accurate results with less time, industries are investing in automated SPE systems.

The machine cost ranges between USD 300 and USD 30,000 that depend on size, quality and various features in the machines, whereas the cost of each SPE cartridge or disk is maximum USD 8 per unit. In automated machines over 12 to 100 samples can be tested at a time which reduces the cost per sample preparation.

  • In July 2018, Fluid Management System (fms-inc), a U.S. based manufacturer of analytical instrument developed a semi-automated solid phase extraction (EZSpe). The company also has several fully automated SPE systems under the brand name EconoTrace, TurboTrace Parallel SPE, TurboTrace Sequential Parallel SPE and many more.

Growing demand of biological fluids tests due to increasing health related issues

The benefit of using SPE is its high selectivity of the molecules or compounds which help in isolating them and gives accurate results. SPE is used in performing the biological analytical tests such as Prostaglandins from urine and blood, 8-iso-prostaglandin F2α from tissue as indicator for oxidative stress, melatonin in human breast cancer tissue, fatty acids, cholesterol and bile acids from tissue and serum, anthraquinone glycosides from feces, nucleosides and orotate from plasma and urine.

  • In 2017, there were estimated 10.0 million new cases of active TB and 1,600,000 related deaths worldwide. The increasing diseases among the population and its appropriate identification and treatment are growing tremendously. Thus, the health related issues is driving the solid phase extraction which is growing due to high requirement of the biological tests.

Drug discovery to boost solid phase extraction

The evaluating of pharmacodynamics and pharmacokinetic characteristics of candidate compounds, metabolism of drug plays dire role in support of drug discovery. The major advantage of using the SPE technique is low consumption of the solvent and high yield. SPE usually employs disposable cartridges filled with sorbents of a small particle size, which is quick and simple to operate. The sample handling losses are avoided and giving easy automation of the pharmacological samples.

Solid phase extraction gives highly accurate results with less time. It aims toward developing miniaturized and automated systems for the analysis of pharmaceuticals and quality control of the drugs. Hence, the on-going investment in drug discovery is expected to drive the solid phase extraction market.

SPE provides more accurate results as compared to its substitutes

Solid-phase extraction has shown tremendous growth in isolation and segregation of the analytes from biological and non-biological matrices. The success of the technique is depended on the relative affinities of analytes between the sample matrix & adsorbent and the relative ease of eluting the analytes for analysis.

The automated SPE system is highly reliable for generation of the accurate and high quality results. Also, results are reproducible which amplifies the usage in the different extraction experiments in various industries. The SPE system is highly selective which the traditional techniques lack. The highly selectivity results in high resolution of the solvents and making the further procedure easier.

The automation of solid phase extraction yield reliable, reproducible and accurate analysis compared to its other substitutes is driving the market for solid phase extraction.


High variation in retail price of SPE products facility

The probes are used for carrying out the sample preparation and analysis. SPE probes which are commercially available are cartridges, disks, columns and tubes. The different prices of the probes are influenced by the availability of probes in different sizes.

SPE probe price ranges from USD 0.2 to USD 8 and depending upon the amount of probes one need to purchase its cost varies. The manufacturing cost of the cartridges and disks are very minimal but there is huge difference between the cost of manufacturing and selling prices.

The manufacturers appoint distributors and reseller to deliver or increase the sale of the solid phase extraction product which leads to increase in the price of the products. Purchasing SPE probes becomes cost efficient if it is in huge volume or bulk. The manufacturer must design and make probes of SPE which are available at the same price. Thus, the variability in the prices of SPE product can restrain the growth of solid phase extraction market.

High investment cost associated with automated solid phase extraction system

The increasing demand of the pharmacological investment requires automated systems for faster and accurate analytical process. The cost automated machines is so high that it increases the cost of testing and diagnosis.

The automated SPE have 96 or 384‐channel programmable liquid‐handling workstation using a mixed‐mode sorbent. It can analyse up to approximately 2,000 samples in a day but the high cost of this machine is major drawback. Thus, this has potential to restrain the market of solid phase extraction.

Stringent Regulations to Meet Environment Laws

The solid phase extraction probes are composed of polymer, silica gel and polyurethane of certain composition. The composition of the probe should meet standards otherwise it gets rejected. The use of these rejected pieces is banned in American and European region.

The waste samples generated from the test may contain toxic and infectious components which can lead to causing disease. Therefore, the process and method should be performed carefully. If the regulations do not meet the standard, the technique gets banned.

  • Environmental Protection Agency (EPA) has selected analytical methods for Environmental Remediation and Recovery (SAM). The method should be followed by the laboratories performing analysis on environmental contaminants.

Hence, the stringent regulations are definitely restrained for the solid phase extraction market.

Availability of low cost substitutes

The solid phase extraction is growing tremendously with its high applicability. But the cost of the probes used in the SPE is quite variable and automated systems as mentioned in the above mentioned restrain regarding high investment cost of these systems.

The availability of the liquid phase extractions, mass spectroscopy (MS) and high performance liquid chromatography (HPLC) are the alternatives which are lower in cost than solid phase extraction. The probe set for liquid phase extraction is costs approximately USD 2,000 while solid phase extraction cost approximately USD 500 which less expensive. It is a major drawback of SPE which can restrain its market in future


Supply of SPE products at low cost

The developing countries such as South Africa, Algeria, Nigeria, Kenya, Indonesia, Thailand and Argentina have high demand for the sample preparation for using solid phase extraction method. Supplying SPE products at low cost will yield higher sales in these countries.

The manufacturers of SPE designs and produce probe at very low cost but they are available at very high prices in the market. The very high margin in price results in less purchasing of the products. The products which can be available at cheaper prices can increase it sale around the globe. Therefore, it is a a great opportunity for the market to grow in the future.


The benefit of using the quenchers is that it helps DisQueD d-SPE products has already packed centrifuged tubes having pre-packaged sorbents. The packed quenchers reduce the chances of the errors and gives accurate results. The advantage of using quenchers is decreased time spent on the sample preparation as the sorbents come pre-measured and packed, efficient and cost effective sample preparation, highly reliable, cost-efficient and high quality product in a very convenient format.

The pesticides have potential to cause toxins in human being and most of the pesticide used in agriculture gets diffused in the environment.

A test was conducted by Monitoring of Pesticide Residues at National Level in India and it founds that, out of 16,790 samples, 509 has high level of pesticides which comprises veggies, fruits, spices, rice, wheat and other food items. Also 7,591 samples were collected from various wholesale and retail markets, located in different parts of the country and analyzed by 25 laboratories and found that 221 out of 7,591 vegetables have pesticides residues above MRL.

Beverage industry showcasing new avenues due to growing demand

The rising demand of the beverage is due to increasing number of working women and nuclear families. It directly gives opportunity for the solid phase extraction market to grow as there are large number of food and other materials which requires a lot food testing, purification and quantification.

The young population, aspiring to improve their standard of living which is expected to drive the growth of the country’s growing beverages sector. Increased preference for convenience and higher instances of drinking out is giving opportunity for the market to grow in the future. Therefore, high demand of the beverage will also give opportunity SPE market to grow in the future.


Lack of expert technicians for the usage of SPE globally

Sample preparation is very critical step for the analysis of different sample which impacts the further processes. Therefore, skilled labors know the amount of solvent used in the sample preparation and the optimum condition requires getting quality of result.

Sold phase extraction is widely done manually, and humans are prone to make mistakes. The sorbent concentration in the sample might get higher or lower and even conditional timings affect the results if adjusted at particular time. Therefore, highly skilled technicians are required to perform the analysis with high accuracy.

High precision requirements for production of disk and cartridge

The size difference of the cartilage and wide range of volume are used for the sample preparation. The sample preparation is the crucial step and it impacts nearly all later stages of the analysis. The efficiency of extraction by cartridge depends on the quality of packing and more uniform packing will give less variation in the sample recovery.

The quality of the material highly impacts the procedure for the bioanalytical performance. Therefore, manufacturing of cartilage and disk requires high precision which is quite challenging for the solid phase extraction market.

Variation in shape of disk and cartridge can hamper the test results

The isolation and extraction efficiency of the compounds is high dependent on the shape and size of the disk and cartilage. The shape of the cartilage and disk affects the absorbance and selectivity of the compound. Therefore, selection of the shape of the compound should be done carefully to avoid affecting the result.

The manufacturers face several problems in making different shape of the cartilage and disk depending upon the requirement of the different analysis. Thus, the variation in the shape of disk and cartilage can hamper the analytical tests which is quite challenging for the solid phase extraction market to grow

Market Trends:

Global solid phase extraction market is segmented into two notable segments which are type and application.

On the basis of type, the market is segmented into SPE cartridge, SPE disk, others. In 2019, SPE cartridge segment is expected to dominate the global solid phase extraction market with 63.18% market share and is expected to reach USD 281,286.68 thousand by 2026 from USD 177,715.84 thousand in 2018, growing at highest CAGR of 5.9% in the forecast period 2019 to 2026.

On the basis of application, the market is segmented into pharmaceuticals, environmental, food & beverage industry, biological fluids and others. In 2019, pharmaceuticals is expected to dominate the global solid phase extraction market with 38.24% market share and is expected to reach USD 167,826.45 thousand by 2026 from USD 107,781.22 thousand in 2018, growing at the CAGR of 5.7% in the forecast period 2019 to 2026. However biological fluids segment is growing with the highest CAGR 6.1% in the forecast period of 2019 to 2026.

 Major Players: Global Solid Phase Extraction Market 

Some of the major players operating in this market are Thermo Fisher Scientific Inc., Agilent Technologies, Inc., PerkinElmer Inc., WATERS, MERCK & CO.,INC., 3M, S*Pure Pte Ltd, JASCO, Phenomenex Inc., Restek Corporation, MACHEREY-NAGEL GmbH & Co. KG, Orochem Technologies Inc., Avantor, Inc., United Chemical Technologies, ANPEL and others.