- In May 2025, ITM Isotope Technologies Munich SE and Radiopharm Theranostics announced a supply agreement for non-carrier-added Lutetium-177 (n.c.a. 177Lu). The partnership supports Radiopharm’s clinical development of Lu-177-based therapies, including RAD 204, RAD 202, and RV01, ensuring high-quality isotope access for targeted radiopharmaceutical treatment of solid tumors in ongoing and future clinical trials
- In March 2025, the FDA approved Novartis’ Pluvicto (Lu-177 vipivotide tetraxetan) for earlier use in PSMA-positive metastatic castration-resistant prostate cancer, allowing administration after one ARPI and before chemotherapy. Based on Phase III PSMAfore trial results, Pluvicto reduced progression or death risk by 59%, doubling median radiographic progression-free survival while maintaining a favorable safety profile and expanding patient access significantly
- In March 2025, Eckert & Ziegler and AtomVie Europe Radiopharma signed a Europe supply agreement for non-carrier added Lutetium-177 (Theralugand). The partnership ensures a stable, high-quality Lu-177 supply for AtomVie’s CDMO radiopharmaceutical operations, supporting early-to-late-stage development worldwide and enhancing both companies' capabilities in radiopharmaceutical innovation, regulatory compliance, and patient-centered nuclear medicine solutions
- In March 2025, Eckert & Ziegler and Actinium Pharmaceuticals signed a supply agreement for high-purity Actinium-225 (Ac-225). The partnership ensures a reliable Ac-225 source to support the development of Actimab-A and other radiotherapeutic candidates targeting AML and solid tumors, strengthening Actinium’s clinical pipeline and addressing Europe isotope supply challenges in precision radiopharmaceutical therapy
- In May 2024, Novartis AG announced its agreement to acquire Mariana Oncology for USD 1 billion upfront and up to USD 750 million in milestone payments. The acquisition strengthens Novartis’ radioligand therapy (RLT) pipeline with preclinical assets targeting solid tumors, including actinium-based candidate MC-339 for small cell lung cancer, and enhances its RLT research, supply, and innovation capabilities
