- In June 2025, A groundbreaking development from Massachusetts Institute of Technology (MIT) engineers has led to a novel nanoparticle-based sensor that enables early cancer detection through a simple urine test. This innovative system relies on engineered nanoparticles that respond to tumor-specific enzymes by releasing short DNA sequences ("barcodes") into the bloodstream, which are then excreted in urine. These DNA barcodes can be analyzed using a paper-based test strip, similar to at-home COVID-19 tests, utilizing CRISPR technology. The appearance of a dark line indicates the presence of cancer-related enzyme activity
- In June 2025, Scientists at NYU Abu Dhabi's Advanced Microfluidics and Microdevices Laboratory (AMMLab) have developed a novel Radially Compartmentalized Paper Chip (RCP-Chip) capable of detecting COVID-19 and other infectious diseases in under 10 minutes. This portable, cost-effective device requires no electricity or specialized lab equipment, functioning with only mild heat (around 65°C). Designed from a single sheet of paper, the RCP-Chip integrates sample ports, vents, fluidic resistors, and reaction chambers, pre-loaded with necessary reagents
- In March 2025, A comprehensive review published in EurekaSelect, "Advancements and Challenges in Paper-Based Diagnostic Devices for Low-Resource Settings," explores the development, applications, and future prospects of Paper-Based Diagnostic Devices (PBDDs). The review emphasizes that PBDDs are a breakthrough for affordable, rapid, and point-of-care diagnostics in low-resource settings, utilizing simple materials with microfluidics and various detection methods
- In September 2024, Scientists at the Institute of Nano Science and Technology (INST), Mohali, India, have developed a novel and cost-effective technique for fabricating paper-based devices using an Advanced PAP (A-PAP) pen. This method provides a practical alternative to conventional sensing techniques that require specialized equipment and expertise, making it ideal for resource-limited settings. The new technique allows for rapid fabrication (around 10 seconds) without heating/drying steps and has been successfully demonstrated for chemical detection of heavy metals and nitrites, as well as biological sensing for dopamine. The versatility extends to complex 3D paper-based devices using origami
- In February 2024, Researchers created a paper-based platform that aids in the rapid detection of bacteria causing antibiotic-resistant infections. This development addresses a critical global health challenge by providing a low-cost, point-of-care solution, particularly valuable in resource-limited settings where rapid identification of resistant strains is crucial for effective treatment and infection control
