A novel corona virus, SARS-CoV-2, appeared in December 2019 in Wuhan, China, spreading much faster than its predecessors and the virus has already infected millions of patients worldwide as of April 19, 2020. As the scope of the current COVID-19 outbreak has reached proportion of pandemics, major international efforts in public health are underway to control the outbreak. However, as definitive treatments for confirmed COVID-19 are yet to be identified, there is considerable interest in repeating existing antiviral drugs for use against COVID-19.
Favipiravir triphosphate is a purine nucleoside analogue. This acts as a competitive inhibitor of RNA-dependent RNA polymerase. It has activities against influenza A and B, including oseltamivir- and zanamivir-resistant influenza viruses, several antimicrobial antiviral drugs, such as SARS-CoV-2. Favipiravir is approved for influenza strains that do not respond to standard antiviral therapy in Japan.
A large number of challenges are being faced by various market players due to the coming of the novel coronavirus, one such issue is the uncertainty surrounding the impact of covid-19 on favipiravir demands. Due to the increased demand of favipiravir for coronavirus treatment and stiff competition between the market players the rice of favipiravir has decreased.
According to the data available even as physicians share the benefits of Favipiravir for mild to moderate COVID-19 patients, a number of general launches are anticipated to intensify the price war that has already begun., Last month, Glenmark Pharma has receive a regulatory approval for Favipravir which has lowered its tablet price to Rs 75 each from Rs 103 earlier, anticipating market competition. 8 other favipiravir brands are at least expected to be launched in the upcoming days. At a price of Rs 59 per tablet, the Hetero Pharma became the third company to launch its generic version of Favipiravir, called Favivir. Previously, Mumbai-based Jenburkt Pharma put the low cost brand to date, Favivent, at Rs 39 per tablet. The company has started stockpiling in Mumbai and aims to expand its share of Maharashtra before it expires nationwide.
With the increasing demand and increasing sale of favipiravir drugs, the competition between the favipiravir drugs manufacturers has increased market, leads to the fall of favipiravir drugs price.
The Corona virus zone is the result of various markets around the world. This is the cause of the widespread closures and isolation that are affecting world economic activity.
In Japan Favipiravir which is an oral antiviral drug approved for the treatment of influenza. It specifically inhibits RNA polymer, which is necessary to copy the virus. Japan has begun a Phase 3 clinical trial. In the United States, a phase 2 study will involve approximately 50 patients with COVID-19, in collaboration with Brigham and the Women's Hospital, Massachusetts General Hospital, and the University of Massachusetts Medical School. In India, a Phase 3 trial began combining two antiviral drugs, favipiravir and umifenovir, in May 2020.
Chemists and pharmacists are in the high demand for the antiviral drug Favipiravir, which was launched under the brand name "fabi-influenza" by Glenmark drugs. It has been approved for limited emergency use in for the COVID-19 patients with mild to moderate symptoms by (ICMR) Indian Council of Medical Research.
The impact of COVID-19 has created an opportunity for the number of patients as there are high chances of adverse health effects of COVID-19 on the people.
As the epidemic intensifies, supply chains can be at significant risk due to over-located locations that can potentially be disrupted. The supply chain of drugs has been disrupted. The spread of COVID-19 makes it difficult for governments to use these drugs; the availability of these systems faces constant challenges due to their components of use as well as limited initial needs.
Lasa Supergenerics already has export orders from abroad. The drug is sought after in Turkey, Jordan, Spain, and Portugal and so on where it is used in COVID-19 patients. Exports have no restrictions as they are based on our own specifications and not under the name of specific pharmacology.
This is an opportunity to confirm that India is indeed the 'Pharmacology of the World'. As the world seems to be using reusable drugs to control COVID-19 until an effective and safe vaccine is developed, India has played a key role in providing some key drugs such as hydroxychloroquine (HCQ) and favipiravir for humanitarian and commercial purposes.
The trade restrictions have chosen nothing more than to produce the necessary medicines domestically. During the pandemic, when the demand increases, counterfeiting and price increases of imported goods increase. This signifies that even during the COVID-19 pandemic the market players are able to maintain supply chain.
STRATEGIC DECISIONS OF GOVERNMENT AND MANUFACTURERS
As the coronavirus continues to spread to various countries, concerns are growing about disruptions in drug production and distribution. Collaborations, agreements, initiatives of market participants such as Fujifilm Corporation in the pharmaceutical market have helped them to expand their market. This in turn will help to increase the demand for the product among the consumers and thus increase the future sales of the company.
Market players have already taken different initiatives to combat the corona virus.
With the increasing demand and increasing sale of favipiravir drugs, are fueling the growth of favipiravir drugs market in the near future. As such, market participants are involved in the production of favipiravir drugs expanding their business through a variety of programs, including collaboration, contracts, and pipeline development, collaboration, and market expansion. It is expected that the strategic decisions of these companies will provide significant opportunities for market participants operating in the favipiravir market.
The available clinical evidence suggests that favipiravir is relatively safe for total cell carcinoma, as well as serious gastrointestinal side effects. However, an increase in the blood uric acid is still a safety issue, as shown in a pooled analysis of larger studies, with evidence of increased dose-dependent development. Further safety concerns, such as the possibility of Corrected QT Interval (QTc) malformation and prolongation, have not yet been adequately investigated.
There is an evidence to support the safety and tolerability of favipiravir during short-term treatment. However, more evidence is needed to assess the effects of long-term treatment. Given the limitations of the evidence and the specific safety concerns that remain, the widespread use of favipiravir against pandemic COVID-19 should be justified. Various manufacturers have allowed their manufacturers to remotely operate the production of favipiravir at various production sites in safe areas around the world and help them maintain a stable supply chain. In addition, increased demand for favipiravir for the treatment of coronavirus has increased profits.